9v3t: Difference between revisions

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'''Unreleased structure'''


The entry 9v3t is ON HOLD  until Paper Publication
==Apo SLC36A1==
<StructureSection load='9v3t' size='340' side='right'caption='[[9v3t]], [[Resolution|resolution]] 3.73&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9v3t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9V3T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9V3T FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.73&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9v3t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9v3t OCA], [https://pdbe.org/9v3t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9v3t RCSB], [https://www.ebi.ac.uk/pdbsum/9v3t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9v3t ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/S36A1_HUMAN S36A1_HUMAN] Electrogenic proton/amino acid symporter with selectivity for small apolar L-amino acids, their D-enantiomers and selected amino acid derivatives such as 4-aminobutanoate/GABA (PubMed:12527723, PubMed:12809675, PubMed:19549785). May be involved in the efflux from the lysosomal compartment of neutral amino acids resulting from proteolysis (By similarity). May play a role in specifying sites for exocytosis in neurons (By similarity).[UniProtKB:Q924A5]<ref>PMID:12527723</ref> <ref>PMID:12809675</ref> <ref>PMID:19549785</ref>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The proton-coupled amino-acid transporter SLC36A1 (hPAT1) is an atypical H(+)-driven carrier and mediates the intestinal absorption of a wide array of zwitterionic amino-acid analogs, including many compounds with central nervous-system (CNS) activity, as well as the activation of the mTORC1 pathway and the export of amino acids from lysosomes, thereby maintaining cellular amino-acid homeostasis. Here, we present the cryo-EM structures of a member of the SLC36 family, hPAT1, in its apo state and in complex with three chemically distinct substrates, including the alpha-amino acid D-serine, the beta-amino acid nipecotic acid, and the heterocyclic drug D-cycloserine, at resolutions of 3.4-3.5 A. Despite their chemical diversity, all ligands adopt a spatially convergent binding mode, elucidating the structural basis for PAT1's broad substrate promiscuity. In addition, we identify E270 as a potential proton-binding site. Together, these findings provide structural insights into the molecular mechanism of proton-coupled amino acid transport. Notably, the cryo-EM structure of PAT1 bound to D-cycloserine illustrates a viable oral CNS drug delivery strategy: exploiting polar scaffolds to achieve transporter-mediated intestinal absorption and blood-brain barrier penetration without relying on high lipophilicity.


Authors:  
Substrate recognition and transport mechanism of the human proton-coupled amino-acid transporter 1 (SLC36A1).,Yin J, Zhang S, Liu C, Xie M, Gao Y, Chen M, Wang Y, Chen M, Fan H, Yang Z, Li H, Liang L, Zhou B, Chen X, Yang M Nat Commun. 2026 Jul 7. doi: 10.1038/s41467-026-75306-z. PMID:42414312<ref>PMID:42414312</ref>


Description:  
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
<div class="pdbe-citations 9v3t" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Zhang SS]]
Retrieved from "https://proteopedia.org/9v3t"