1w6b: Difference between revisions

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[[Image:1w6b.jpg|left|200px]]
{{Seed}}
[[Image:1w6b.png|left|200px]]


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{{STRUCTURE_1w6b|  PDB=1w6b  |  SCENE=  }}  
{{STRUCTURE_1w6b|  PDB=1w6b  |  SCENE=  }}  


'''SOLUTION NMR STRUCTURE OF A LONG NEUROTOXIN FROM THE VENOM OF THE ASIAN COBRA, 20 STRUCTURES'''
===SOLUTION NMR STRUCTURE OF A LONG NEUROTOXIN FROM THE VENOM OF THE ASIAN COBRA, 20 STRUCTURES===




==Overview==
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The NMR solution structures of NTX-1 (PDB code 1W6B and BMRB 6288), a long neurotoxin isolated from the venom of Naja naja oxiana, and the molecular dynamics simulation of these structures are reported. Calculations are based on 1114 NOEs, 19 hydrogen bonds, 19 dihedral angle restraints and secondary chemical shifts derived from 1H to 13C HSQC spectrum. Similar to other long neurotoxins, the three-finger like structure shows a double and a triple stranded beta-sheet as well as some flexible regions, particularly at the tip of loop II and the C-terminal tail. The solution NMR and molecular dynamics simulated structures are in good agreement with root mean square deviation values of 0.23 and 1 A for residues involved in beta-sheet regions, respectively. The overall fold in the NMR structure is similar to that of the X-ray crystallography, although some differences exist in loop I and the tip of loop II. The most functionally important residues are located at the tip of loop II and it appears that the mobility and the local structure in this region modulate the binding of NTX-1 and other long neurotoxins to the nicotinic acetylcholine receptor.
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{{ABSTRACT_PUBMED_15606783}}


==About this Structure==
==About this Structure==
1W6B is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Naja_oxiana Naja oxiana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W6B OCA].  
1W6B is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Naja_oxiana Naja oxiana]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W6B OCA].  


==Reference==
==Reference==
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[[Category: Toxin]]
[[Category: Toxin]]
[[Category: Venom]]
[[Category: Venom]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 13:12:59 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:09:41 2008''

Revision as of 03:09, 29 July 2008

File:1w6b.png

Template:STRUCTURE 1w6b

SOLUTION NMR STRUCTURE OF A LONG NEUROTOXIN FROM THE VENOM OF THE ASIAN COBRA, 20 STRUCTURES

Template:ABSTRACT PUBMED 15606783

About this Structure

1W6B is a Single protein structure of sequence from Naja oxiana. Full experimental information is available from OCA.

Reference

Solution structure of long neurotoxin NTX-1 from the venom of Naja naja oxiana by 2D-NMR spectroscopy., Talebzadeh-Farooji M, Amininasab M, Elmi MM, Naderi-Manesh H, Sarbolouki MN, Eur J Biochem. 2004 Dec;271(23-24):4950-7. PMID:15606783

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