9rfu: Difference between revisions
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==M.tuberculosis MmpS5L5-acpM complex== | |||
<StructureSection load='9rfu' size='340' side='right'caption='[[9rfu]], [[Resolution|resolution]] 3.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9rfu]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis], [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv] and [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis_MC2_155 Mycolicibacterium smegmatis MC2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9RFU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9RFU FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4HH:O-[(S)-HYDROXY{[(3R)-3-HYDROXY-2,2-DIMETHYL-4-OXO-4-({3-OXO-3-[(2-SULFANYLETHYL)AMINO]PROPYL}AMINO)BUTYL]OXY}PHOSPHORYL]-L-SERINE'>4HH</scene>, <scene name='pdbligand=L9Q:(1S)-2-{[(S)-(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(OCTADECANOYLOXY)METHYL]ETHYL+(9Z)-OCTADEC-9-ENOATE'>L9Q</scene></td></tr> | ||
[[Category: Fountain | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9rfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9rfu OCA], [https://pdbe.org/9rfu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9rfu RCSB], [https://www.ebi.ac.uk/pdbsum/9rfu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9rfu ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Function == | ||
[https://www.uniprot.org/uniprot/MMPS5_MYCTU MMPS5_MYCTU] Part of an export system, which is required for biosynthesis and secretion of siderophores. Essential for virulence.<ref>PMID:23431276</ref> Overexpression of the system confers non-target based resistance to azoles, clofazimine and bedaquiline, via an efflux mechanism.<ref>PMID:18851927</ref> <ref>PMID:25010492</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mycobacterium tuberculosis]] | |||
[[Category: Mycobacterium tuberculosis H37Rv]] | |||
[[Category: Mycolicibacterium smegmatis MC2 155]] | |||
[[Category: Fountain AJ]] | |||
[[Category: Luisi BF]] | |||
[[Category: Ramakrishnan L]] | |||
Latest revision as of 08:28, 13 August 2025
M.tuberculosis MmpS5L5-acpM complex
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