9i9g: Difference between revisions
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==Crystal structure of human eIF4A1 C-terminal domain in complex with hippuristanol== | |||
<StructureSection load='9i9g' size='340' side='right'caption='[[9i9g]], [[Resolution|resolution]] 1.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9i9g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9I9G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9I9G FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1I1L:(1~{S},2~{S},3~{S},4~{S},6~{R},7~{R},8~{R},9~{S},11~{S},12~{S},13~{S},16~{R},18~{S})-2,2,3,7,9,13-hexamethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosane-6,5-oxolane]-7,11,16-triol'>A1I1L</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9i9g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9i9g OCA], [https://pdbe.org/9i9g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9i9g RCSB], [https://www.ebi.ac.uk/pdbsum/9i9g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9i9g ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/IF4A1_HUMAN IF4A1_HUMAN] ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.<ref>PMID:19153607</ref> <ref>PMID:19204291</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Bushell M]] | |||
[[Category: Schmidt T]] | |||
[[Category: Turnbull AP]] | |||
Latest revision as of 07:05, 18 February 2026
Crystal structure of human eIF4A1 C-terminal domain in complex with hippuristanol
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