1w9d: Difference between revisions

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[[Image:1w9d.~~gif~~|left|200px]]

[[Image:1w9d.png|left|200px]]

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~~'''~~S. ALBA MYROSINASE IN COMPLEX WITH S-ETHYL PHENYLACETOTHIOHYDROXIMATE-O-SULFATE~~'''~~

===S. ALBA MYROSINASE IN COMPLEX WITH S-ETHYL PHENYLACETOTHIOHYDROXIMATE-O-SULFATE===

~~==Overview==~~

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~~Myrosinase~~, ~~a thioglucoside glucohydrolase~~, is the ~~only enzyme able~~ to ~~hydrolyse glucosinolates, a unique family of molecules bearing an anomeric O-sulfated thiohydroximate function~~. ~~Non-hydrolysable myrosinase inhibitors have been devised and studied for their biological interaction~~. ~~Diverse modifications of the O-sulfate moiety did not result in a significant inhibitory effect~~, ~~whereas replacing~~ the ~~D-glucopyrano residue by its carba-analogue allowed inhibition to take place~~. X-~~Ray experiments carried out after soaking allowed for the first time inclusion of a non~~-~~hydrolysable inhibitor inside the enzymatic pocket. Structural tuning of the aglycon part in its pocket is being used as a guide for the development of simplified and more potent inhibitors.~~

The line below this paragraph, {{ABSTRACT_PUBMED_15889170}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 15889170 is the PubMed ID number.

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==About this Structure==

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[[Category: Thioglycosidase]]

[[Category: Thiohydroximate]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 13~~:20:26 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:18:04 2008''

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-[[Image:1w9d.gif|left|200px]]
+{{Seed}}
+[[Image:1w9d.png|left|200px]]
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 {{STRUCTURE_1w9d|  PDB=1w9d  |  SCENE=  }}
-'''S. ALBA MYROSINASE IN COMPLEX WITH S-ETHYL PHENYLACETOTHIOHYDROXIMATE-O-SULFATE'''
+===S. ALBA MYROSINASE IN COMPLEX WITH S-ETHYL PHENYLACETOTHIOHYDROXIMATE-O-SULFATE===
-==Overview==
+<!--
-Myrosinase, a thioglucoside glucohydrolase, is the only enzyme able to hydrolyse glucosinolates, a unique family of molecules bearing an anomeric O-sulfated thiohydroximate function. Non-hydrolysable myrosinase inhibitors have been devised and studied for their biological interaction. Diverse modifications of the O-sulfate moiety did not result in a significant inhibitory effect, whereas replacing the D-glucopyrano residue by its carba-analogue allowed inhibition to take place. X-Ray experiments carried out after soaking allowed for the first time inclusion of a non-hydrolysable inhibitor inside the enzymatic pocket. Structural tuning of the aglycon part in its pocket is being used as a guide for the development of simplified and more potent inhibitors.
+The line below this paragraph, {{ABSTRACT_PUBMED_15889170}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15889170 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_15889170}}
 ==About this Structure==
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 [[Category: Thioglycosidase]]
 [[Category: Thiohydroximate]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 13:20:26 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:18:04 2008''