1wa8: Difference between revisions

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[[Image:1wa8.gif|left|200px]]
{{Seed}}
[[Image:1wa8.png|left|200px]]


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{{STRUCTURE_1wa8|  PDB=1wa8  |  SCENE=  }}  
{{STRUCTURE_1wa8|  PDB=1wa8  |  SCENE=  }}  


'''SOLUTION STRUCTURE OF THE CFP-10.ESAT-6 COMPLEX. MAJOR VIRULENCE DETERMINANTS OF PATHOGENIC MYCOBACTERIA'''
===SOLUTION STRUCTURE OF THE CFP-10.ESAT-6 COMPLEX. MAJOR VIRULENCE DETERMINANTS OF PATHOGENIC MYCOBACTERIA===




==Overview==
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The secreted Mycobacterium tuberculosis complex proteins CFP-10 and ESAT-6 have recently been shown to play an essential role in tuberculosis pathogenesis. We have determined the solution structure of the tight, 1:1 complex formed by CFP-10 and ESAT-6, and employed fluorescence microscopy to demonstrate specific binding of the complex to the surface of macrophage and monocyte cells. A striking feature of the complex is the long flexible arm formed by the C-terminus of CFP-10, which was found to be essential for binding to the surface of cells. The surface features of the CFP-10.ESAT-6 complex, together with observed binding to specific host cells, strongly suggest a key signalling role for the complex, in which binding to cell surface receptors leads to modulation of host cell behaviour to the advantage of the pathogen.
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{{ABSTRACT_PUBMED_15973432}}


==About this Structure==
==About this Structure==
1WA8 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mycobacterium_bovis Mycobacterium bovis] and [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WA8 OCA].  
1WA8 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mycobacterium_bovis Mycobacterium bovis] and [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WA8 OCA].  


==Reference==
==Reference==
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[[Category: Tbsgc]]
[[Category: Tbsgc]]
[[Category: Tuberculosis,cfp-10,esat-6,helix-turn-helix,four helix bundle,mycobacteria,pathogenesis,nmr,solution structure]]
[[Category: Tuberculosis,cfp-10,esat-6,helix-turn-helix,four helix bundle,mycobacteria,pathogenesis,nmr,solution structure]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 13:22:34 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:43:09 2008''
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