9pm0: Difference between revisions

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'''Unreleased structure'''


The entry 9pm0 is ON HOLD  until Paper Publication
==nucleosome containing histone variant macroH2A==
 
<StructureSection load='9pm0' size='340' side='right'caption='[[9pm0]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
Authors: Tan, D., Sokolova, V.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9pm0]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus], [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9PM0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9PM0 FirstGlance]. <br>
Description: nucleosome containing histone variant macroH2A
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9pm0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9pm0 OCA], [https://pdbe.org/9pm0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9pm0 RCSB], [https://www.ebi.ac.uk/pdbsum/9pm0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9pm0 ProSAT]</span></td></tr>
[[Category: Sokolova, V]]
</table>
[[Category: Tan, D]]
== Function ==
[https://www.uniprot.org/uniprot/H2AY_HUMAN H2AY_HUMAN] Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in stable X chromosome inactivation. Inhibits the binding of transcription factors and interferes with the activity of remodeling SWI/SNF complexes. Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces a hypoacetylated state of chromatin. In addition, isoform 1, but not isoform 2, binds ADP-ribose and O-acetyl-ADP-ribose, and may be involved in ADP-ribose-mediated chromatin modulation.<ref>PMID:12718888</ref> <ref>PMID:15621527</ref> <ref>PMID:15897469</ref> <ref>PMID:16428466</ref> <ref>PMID:16107708</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Synthetic construct]]
[[Category: Xenopus laevis]]
[[Category: Sokolova V]]
[[Category: Tan D]]
Retrieved from "https://proteopedia.org/9pm0"