9ryc: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 9ryc is ~~ON HOLD until Paper Publication~~

==Structure of human 1918 influenza A polymerase heterotrimer in complex with WSN NEP.==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[9ryc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Brevig_Mission/1/1918(H1N1)) Influenza A virus (A/Brevig Mission/1/1918(H1N1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9RYC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9RYC FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.93Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ryc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ryc OCA], [https://pdbe.org/9ryc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ryc RCSB], [https://www.ebi.ac.uk/pdbsum/9ryc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ryc ProSAT]</span></td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/PA_I18A0 PA_I18A0] Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits. The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching. It consists in the hijacking and cleavage of host capped pre-mRNAs. These short capped RNAs are then used as primers for viral mRNAs. The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity.[HAMAP-Rule:MF_04063]

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Carrique L]]

[[Category: Chen K]]

[[Category: Fodor M]]

[[Category: Grimes JM]]

[[Category: Rep A]]

[[Category: Wang F]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9ryc is ON HOLD  until Paper Publication
+==Structure of human 1918 influenza A polymerase heterotrimer in complex with WSN NEP.==
+<StructureSection load='9ryc' size='340' side='right'caption='[[9ryc]], [[Resolution|resolution]] 2.93&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9ryc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Brevig_Mission/1/1918(H1N1)) Influenza A virus (A/Brevig Mission/1/1918(H1N1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9RYC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9RYC FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.93&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ryc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ryc OCA], [https://pdbe.org/9ryc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ryc RCSB], [https://www.ebi.ac.uk/pdbsum/9ryc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ryc ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PA_I18A0 PA_I18A0] Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits. The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching. It consists in the hijacking and cleavage of host capped pre-mRNAs. These short capped RNAs are then used as primers for viral mRNAs. The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity.[HAMAP-Rule:MF_04063]
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Carrique L]]
+[[Category: Chen K]]
+[[Category: Fodor M]]
+[[Category: Grimes JM]]
+[[Category: Rep A]]
+[[Category: Wang F]]