9s2c: Difference between revisions

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'''Unreleased structure'''


The entry 9s2c is ON HOLD  until Paper Publication
==CgCdr1 in complex with ATP, ADP-VO4==
 
<StructureSection load='9s2c' size='340' side='right'caption='[[9s2c]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
Authors: Pata, J., Zarkadas, E., Schoehn, G., Chaptal, V., Falson, P.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9s2c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_glabrata Candida glabrata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9S2C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9S2C FirstGlance]. <br>
Description: CgCdr1 in complex with ATP, ADP-VO4
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=ERG:ERGOSTEROL'>ERG</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=VO4:VANADATE+ION'>VO4</scene></td></tr>
[[Category: Zarkadas, E]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9s2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9s2c OCA], [https://pdbe.org/9s2c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9s2c RCSB], [https://www.ebi.ac.uk/pdbsum/9s2c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9s2c ProSAT]</span></td></tr>
[[Category: Pata, J]]
</table>
[[Category: Falson, P]]
== Function ==
[[Category: Schoehn, G]]
[https://www.uniprot.org/uniprot/CDR1_CANGA CDR1_CANGA] Pleiotropic ABC efflux transporter that transports and confers resistance to structurally and functionally unrelated compounds including rhodamine 6G, Nile red, caspofungin, cycloheximide, or azoles such as fluconazole, itraconazole, ketoconazole, posaconazole, voriconazole, and isavuconazole (PubMed:10543759, PubMed:12244114, PubMed:15105111, PubMed:15105136, PubMed:15388433, PubMed:15498768, PubMed:16803598, PubMed:17581937, PubMed:18591262, PubMed:20038613, PubMed:20450660, PubMed:21134356, PubMed:21408004, PubMed:22788839, PubMed:26482310, PubMed:27486188, PubMed:29371812, PubMed:29784839). Chlorbromuron, itraconazole, yohimbine, ketoconazole, miconazole, clotrimazole, DE-11, tamoxifen, quinidine, verapamil can compete for rhodamine 6G's binding site(s) while compounds such as propanil, chloramphenicol, benomyl, voriconazole, tritylimidazole, ketoconazole, miconazole, tamoxifen, gefitinib shared binding site(s) with fluconazole. Nile red mediated efflux appears to be relatively more specific since only five compounds such as ZW3-12, rhodamine 123, miconazole, clotrimazole, and itraconazole can inhibit its accumulation (PubMed:21134356). Does not use as substrates 4-nitroquinoline 1-oxide (4-NQO) and disulfiram (PubMed:21134356). Does not play a role in the azole resistance in mature biofilms (PubMed:18651314).<ref>PMID:10543759</ref> <ref>PMID:12244114</ref> <ref>PMID:15105111</ref> <ref>PMID:15105136</ref> <ref>PMID:15388433</ref> <ref>PMID:15498768</ref> <ref>PMID:16803598</ref> <ref>PMID:17581937</ref> <ref>PMID:18591262</ref> <ref>PMID:18651314</ref> <ref>PMID:20038613</ref> <ref>PMID:20450660</ref> <ref>PMID:21134356</ref> <ref>PMID:21408004</ref> <ref>PMID:22788839</ref> <ref>PMID:26482310</ref> <ref>PMID:27486188</ref> <ref>PMID:29371812</ref> <ref>PMID:29784839</ref>
[[Category: Chaptal, V]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Chaptal V]]
[[Category: Falson P]]
[[Category: Pata J]]
[[Category: Schoehn G]]
[[Category: Zarkadas E]]
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