9s2h: Difference between revisions

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'''Unreleased structure'''


The entry 9s2h is ON HOLD  until Paper Publication
==CgCdr1 in complex with ATP and ADP==
 
<StructureSection load='9s2h' size='340' side='right'caption='[[9s2h]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
Authors: Pata, J., Zarkadas, E., Schoehn, G., Chaptal, V., Falson, P.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9s2h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_glabrata Candida glabrata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9S2H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9S2H FirstGlance]. <br>
Description: CgCdr1 in complex with ATP and ADP
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=ERG:ERGOSTEROL'>ERG</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
[[Category: Zarkadas, E]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9s2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9s2h OCA], [https://pdbe.org/9s2h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9s2h RCSB], [https://www.ebi.ac.uk/pdbsum/9s2h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9s2h ProSAT]</span></td></tr>
[[Category: Pata, J]]
</table>
[[Category: Falson, P]]
== Function ==
[[Category: Schoehn, G]]
[https://www.uniprot.org/uniprot/CDR1_CANGA CDR1_CANGA] Pleiotropic ABC efflux transporter that transports and confers resistance to structurally and functionally unrelated compounds including rhodamine 6G, Nile red, caspofungin, cycloheximide, or azoles such as fluconazole, itraconazole, ketoconazole, posaconazole, voriconazole, and isavuconazole (PubMed:10543759, PubMed:12244114, PubMed:15105111, PubMed:15105136, PubMed:15388433, PubMed:15498768, PubMed:16803598, PubMed:17581937, PubMed:18591262, PubMed:20038613, PubMed:20450660, PubMed:21134356, PubMed:21408004, PubMed:22788839, PubMed:26482310, PubMed:27486188, PubMed:29371812, PubMed:29784839). Chlorbromuron, itraconazole, yohimbine, ketoconazole, miconazole, clotrimazole, DE-11, tamoxifen, quinidine, verapamil can compete for rhodamine 6G's binding site(s) while compounds such as propanil, chloramphenicol, benomyl, voriconazole, tritylimidazole, ketoconazole, miconazole, tamoxifen, gefitinib shared binding site(s) with fluconazole. Nile red mediated efflux appears to be relatively more specific since only five compounds such as ZW3-12, rhodamine 123, miconazole, clotrimazole, and itraconazole can inhibit its accumulation (PubMed:21134356). Does not use as substrates 4-nitroquinoline 1-oxide (4-NQO) and disulfiram (PubMed:21134356). Does not play a role in the azole resistance in mature biofilms (PubMed:18651314).<ref>PMID:10543759</ref> <ref>PMID:12244114</ref> <ref>PMID:15105111</ref> <ref>PMID:15105136</ref> <ref>PMID:15388433</ref> <ref>PMID:15498768</ref> <ref>PMID:16803598</ref> <ref>PMID:17581937</ref> <ref>PMID:18591262</ref> <ref>PMID:18651314</ref> <ref>PMID:20038613</ref> <ref>PMID:20450660</ref> <ref>PMID:21134356</ref> <ref>PMID:21408004</ref> <ref>PMID:22788839</ref> <ref>PMID:26482310</ref> <ref>PMID:27486188</ref> <ref>PMID:29371812</ref> <ref>PMID:29784839</ref>
[[Category: Chaptal, V]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Chaptal V]]
[[Category: Falson P]]
[[Category: Pata J]]
[[Category: Schoehn G]]
[[Category: Zarkadas E]]
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