9rtx: Difference between revisions
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==Mammalian AP3 complex on tubular membranes (ARF1 centered Beta3-ARF1 dimer-Beta3 interface)== | |||
<StructureSection load='9rtx' size='340' side='right'caption='[[9rtx]], [[Resolution|resolution]] 8.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9rtx]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Pan_troglodytes Pan troglodytes] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9RTX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9RTX FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 8.5Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9rtx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9rtx OCA], [https://pdbe.org/9rtx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9rtx RCSB], [https://www.ebi.ac.uk/pdbsum/9rtx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9rtx ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/A0A2I3SW12_PANTR A0A2I3SW12_PANTR] Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.[ARBA:ARBA00023570] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Pan troglodytes]] | |||
[[Category: Rattus norvegicus]] | |||
[[Category: Briggs JAG]] | |||
[[Category: Kaufman JGG]] | |||
[[Category: Owen DJ]] | |||
[[Category: Tagiltsev G]] | |||
Latest revision as of 04:59, 27 May 2026
Mammalian AP3 complex on tubular membranes (ARF1 centered Beta3-ARF1 dimer-Beta3 interface)
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