9vgt: Difference between revisions

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'''Unreleased structure'''


The entry 9vgt is ON HOLD  until Paper Publication
==Crystal structure of Peroxiredoxin I in complex with compound 19-150==
 
<StructureSection load='9vgt' size='340' side='right'caption='[[9vgt]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
Authors: Zhang, H., Wang, X.M.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9vgt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9VGT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9VGT FirstGlance]. <br>
Description: Crystal structure of Peroxiredoxin I in complex with compound 19-150
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.79&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1ESV:methyl+(2~{S})-2-[[(2~{R},4~{a}~{S},6~{a}~{S},6~{a}~{R},13~{S},14~{a}~{S},14~{b}~{R})-13-bromanyl-2,4~{a},6~{a},6~{a},9,14~{a}-hexamethyl-10-oxidanyl-11-oxidanylidene-1,3,4,5,6,13,14,14~{b}-octahydropicen-2-yl]carbamoylamino]propanoate'>A1ESV</scene></td></tr>
[[Category: Zhang, H]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9vgt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9vgt OCA], [https://pdbe.org/9vgt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9vgt RCSB], [https://www.ebi.ac.uk/pdbsum/9vgt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9vgt ProSAT]</span></td></tr>
[[Category: Wang, X.M]]
</table>
== Function ==
[https://www.uniprot.org/uniprot/PRDX1_HUMAN PRDX1_HUMAN] Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity).
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Wang XM]]
[[Category: Zhang H]]
Retrieved from "https://proteopedia.org/9vgt"