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| [[Image:1wct.jpg|left|200px]] | | {{Seed}} |
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| {{STRUCTURE_1wct| PDB=1wct | SCENE= }} | | {{STRUCTURE_1wct| PDB=1wct | SCENE= }} |
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| '''A NOVEL CONOTOXIN FROM CONUS TEXTILE WITH UNUSUAL POST-TRANSLATIONAL MODIFICATIONS REDUCES PRESYNAPTIC CALCIUM INFLUX, NMR, 1 STRUCTURE, GLYCOSYLATED PROTEIN'''
| | ===A NOVEL CONOTOXIN FROM CONUS TEXTILE WITH UNUSUAL POST-TRANSLATIONAL MODIFICATIONS REDUCES PRESYNAPTIC CALCIUM INFLUX, NMR, 1 STRUCTURE, GLYCOSYLATED PROTEIN=== |
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| ==Overview==
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| Cone snails are gastropod mollusks of the genus Conus that live in tropical marine habitats. They are predators that paralyze their prey by injection of venom containing a plethora of small, conformationally constrained peptides (conotoxins). We report the identification, characterization, and structure of a gamma-carboxyglutamic acid-containing peptide, conotoxin epsilon-TxIX, isolated from the venom of the molluscivorous cone snail, Conus textile. The disulfide bonding pattern of the four cysteine residues, an unparalleled degree of posttranslational processing including bromination, hydroxylation, and glycosylation define a family of conotoxins that may target presynaptic Ca2+ channels or act on G protein-coupled presynaptic receptors via another mechanism. This conotoxin selectively reduces neurotransmitter release at an Aplysia cholinergic synapse by reducing the presynaptic influx of Ca2+ in a slow and reversible fashion. The three-dimensional structure, determined by two-dimensional 1H NMR spectroscopy, identifies an electronegative patch created by the side chains of two gamma-carboxyglutamic acid residues that extend outward from a cavernous cleft. The glycosylated threonine and hydroxylated proline enclose a localized hydrophobic region centered on the brominated tryptophan residue within the constrained intercysteine region.
| | The line below this paragraph, {{ABSTRACT_PUBMED_10318957}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 10318957 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_10318957}} |
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| ==About this Structure== | | ==About this Structure== |
| 1WCT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Conus_textile Conus textile]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WCT OCA]. | | 1WCT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Conus_textile Conus textile]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WCT OCA]. |
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| ==Reference== | | ==Reference== |
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| [[Category: Gamma-carboxy glutamic acid]] | | [[Category: Gamma-carboxy glutamic acid]] |
| [[Category: Novel omega conotoxin]] | | [[Category: Novel omega conotoxin]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:28:49 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:18:36 2008'' |
