9ozx: Difference between revisions
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==Crystal structure of ZNRF3 RING in complex with UbcH5b== | |||
<StructureSection load='9ozx' size='340' side='right'caption='[[9ozx]], [[Resolution|resolution]] 2.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9ozx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9OZX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9OZX FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ozx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ozx OCA], [https://pdbe.org/9ozx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ozx RCSB], [https://www.ebi.ac.uk/pdbsum/9ozx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ozx ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/ZNRF3_HUMAN ZNRF3_HUMAN] Adrenocortical carcinoma. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ZNRF3_HUMAN ZNRF3_HUMAN] E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby restricting the size of the intestinal stem cell zone (PubMed:22575959). Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification (By similarity).[UniProtKB:Q08D68]<ref>PMID:22575959</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Day CL]] | |||
[[Category: Middleton AJ]] | |||
[[Category: Padala P]] | |||
Latest revision as of 07:10, 17 June 2026
Crystal structure of ZNRF3 RING in complex with UbcH5b
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