9p0k: Difference between revisions
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==Composite map of CXCL9-CXCR3-Gi-scFv16== | |||
<StructureSection load='9p0k' size='340' side='right'caption='[[9p0k]], [[Resolution|resolution]] 3.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9p0k]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9P0K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9P0K FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9p0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9p0k OCA], [https://pdbe.org/9p0k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9p0k RCSB], [https://www.ebi.ac.uk/pdbsum/9p0k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9p0k ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
C-X-C motif chemokine receptor 3 (CXCR3) is essential for immune cell functions and pivotal in T helper 1 cell infiltration in autoimmune and chronic inflammatory diseases and in tumor proliferation and metastasis, but the mechanisms by which the endogenous ligands CXCL9, CXCL10, and CXCL11 differentially recognize and activate CXCR3 are not fully understood. Here, we present cryo-electron microscopy structures of all three chemokine-CXCR3-G(i) complexes, complemented by cell binding studies and functional mutagenesis data. We systematically compare the pharmacological and interaction profiles of CXCL9, CXCL10, and CXCL11 to rationalize their varying efficacies and potencies and to reveal the critical role of the membrane-distal CXCR3 N terminus in ligand binding and signaling. Using chimeric chemokines and molecular dynamics, we reveal the signaling plasticity of chemokine ligands and signaling determinants. Together, these insights enable us to propose a multimodal binding and activation framework that explains CXCR3 chemokine ligand multispecificity and signaling versatility and offer tools to interrogate and modulate CXCR3 biology. | |||
Molecular basis of CXC chemokine receptor 3 ligand multispecificity.,Bouyssou A, Sun D, Zhou T, Smith S, Ho H, Johnson M, Azumaya C, Noreng S, Liu P, Ti S, Joshi P, Tam C, Yang Y, Janezic E, Comps-Agrar L, Masureel M Sci Adv. 2026 Apr 17;12(16):eadz3767. doi: 10.1126/sciadv.adz3767. Epub 2026 Apr , 17. PMID:41996512<ref>PMID:41996512</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 9p0k" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Johnson M]] | |||
[[Category: Masureel M]] | |||
[[Category: Sun D]] | |||
Latest revision as of 08:13, 29 April 2026
Composite map of CXCL9-CXCR3-Gi-scFv16
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