1zp5: Difference between revisions

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[[Image:1zp5.gif|left|200px]]<br />

[[Image:1zp5.gif|left|200px]]<br /><applet load="1zp5" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="1zp5" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="1zp5, resolution 1.80Å" />

'''Crystal structure of the complex between MMP-8 and a N-hydroxyurea inhibitor'''<br />

==Overview==

The first crystallographic structure of an N-hydroxyurea inhibitor bound, into the active site of a matrix metalloproteinase is reported. The ligand, and three other analogues were prepared and studied as inhibitors of, MMP-2, MMP-3, and MMP-8. The crystal structure of the complex with MMP-8, shows that the N-hydroxyurea, contrary to the analogous hydroxamate, binds, the catalytic zinc ion in a monodentate rather than bidentate mode and, with high out-of-plane distortion of the amide bonds.

The first crystallographic structure of an N-hydroxyurea inhibitor bound into the active site of a matrix metalloproteinase is reported. The ligand and three other analogues were prepared and studied as inhibitors of MMP-2, MMP-3, and MMP-8. The crystal structure of the complex with MMP-8 shows that the N-hydroxyurea, contrary to the analogous hydroxamate, binds the catalytic zinc ion in a monodentate rather than bidentate mode and with high out-of-plane distortion of the amide bonds.

==About this Structure==

1ZP5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CA, ZN and 2NI as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Neutrophil_collagenase Neutrophil collagenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.34 3.4.24.34] Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1ZP5 OCA].

1ZP5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=2NI:'>2NI</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Neutrophil_collagenase Neutrophil collagenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.34 3.4.24.34] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZP5 OCA].

==Reference==

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[[Category: hydrolase]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov 12 20~~:38:~~09 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:17:50 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1zp5.gif|left|200px]]<br />
+[[Image:1zp5.gif|left|200px]]<br /><applet load="1zp5" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="1zp5" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="1zp5, resolution 1.80&Aring;" />
 '''Crystal structure of the complex between MMP-8 and a N-hydroxyurea inhibitor'''<br />
 ==Overview==
-The first crystallographic structure of an N-hydroxyurea inhibitor bound, into the active site of a matrix metalloproteinase is reported. The ligand, and three other analogues were prepared and studied as inhibitors of, MMP-2, MMP-3, and MMP-8. The crystal structure of the complex with MMP-8, shows that the N-hydroxyurea, contrary to the analogous hydroxamate, binds, the catalytic zinc ion in a monodentate rather than bidentate mode and, with high out-of-plane distortion of the amide bonds.
+The first crystallographic structure of an N-hydroxyurea inhibitor bound into the active site of a matrix metalloproteinase is reported. The ligand and three other analogues were prepared and studied as inhibitors of MMP-2, MMP-3, and MMP-8. The crystal structure of the complex with MMP-8 shows that the N-hydroxyurea, contrary to the analogous hydroxamate, binds the catalytic zinc ion in a monodentate rather than bidentate mode and with high out-of-plane distortion of the amide bonds.
 ==About this Structure==
-ZP5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CA, ZN and 2NI as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Neutrophil_collagenase Neutrophil collagenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.34 3.4.24.34] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1ZP5 OCA].
+ZP5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=2NI:'>2NI</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Neutrophil_collagenase Neutrophil collagenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.34 3.4.24.34] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZP5 OCA].
 ==Reference==
@@ Line 30: / Line 29: @@
 [[Category: hydrolase]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 20:38:09 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:17:50 2008''