1weh: Difference between revisions

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[[Image:1weh.jpg|left|200px]]
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'''Crystal structure of the conserved hypothetical protein TT1887 from Thermus thermophilus HB8'''
===Crystal structure of the conserved hypothetical protein TT1887 from Thermus thermophilus HB8===




==Overview==
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TT1887 and TT1465 from Thermus thermophilus HB8 are conserved hypothetical proteins, and are annotated as possible lysine decarboxylases in the Pfam database. Here we report the crystal structures of TT1887 and TT1465 at 1.8 A and 2.2 A resolutions, respectively, as determined by the multiwavelength anomalous dispersion (MAD) method. TT1887 is a homotetramer, while TT1465 is a homohexamer in the crystal and in solution. The structures of the TT1887 and TT1465 monomers contain single domains with the Rossmann fold, comprising six alpha helices and seven beta strands, and are quite similar to each other. The major structural differences exist in the N terminus of TT1465, where there are two additional alpha helices. A comparison of the structures revealed the elements that are responsible for the different oligomerization modes. The distributions of the electrostatic potential on the solvent-accessible surfaces suggested putative active sites.
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==About this Structure==
==About this Structure==
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[[Category: Rsgi]]
[[Category: Rsgi]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 13:32:16 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:22:58 2008''

Revision as of 09:23, 28 July 2008

File:1weh.png

Template:STRUCTURE 1weh

Crystal structure of the conserved hypothetical protein TT1887 from Thermus thermophilus HB8

Template:ABSTRACT PUBMED 15459330

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystal structures of possible lysine decarboxylases from Thermus thermophilus HB8., Kukimoto-Niino M, Murayama K, Kato-Murayama M, Idaka M, Bessho Y, Tatsuguchi A, Ushikoshi-Nakayama R, Terada T, Kuramitsu S, Shirouzu M, Yokoyama S, Protein Sci. 2004 Nov;13(11):3038-42. Epub 2004 Sep 30. PMID:15459330

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