9wcw: Difference between revisions
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==AMP-PNP bound E.coli CnoX-GroEL complex, state I== | |||
<StructureSection load='9wcw' size='340' side='right'caption='[[9wcw]], [[Resolution|resolution]] 2.73Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9wcw]] is a 28 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9WCW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9WCW FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.73Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
[[Category: Kim | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9wcw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9wcw OCA], [https://pdbe.org/9wcw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9wcw RCSB], [https://www.ebi.ac.uk/pdbsum/9wcw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9wcw ProSAT]</span></td></tr> | ||
[[Category: Roh | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/CNOX_ECOLI CNOX_ECOLI] Chaperedoxin that combines a chaperone activity with a redox-protective function (PubMed:16563353, PubMed:18657513, PubMed:29754824). Involved in the protection against hypochlorous acid (HOCl), the active ingredient of bleach, which kills bacteria by causing protein aggregation (PubMed:29754824). Functions as an efficient holdase chaperone that protects the substrates of the major folding systems GroEL/GroES and DnaK/DnaJ/GrpE from aggregation. In addition, it prevents the irreversible oxidation of its substrates through the formation of mixed disulfide complexes (PubMed:29754824). After bleach stress, it transfers its substrates to the GroEL/GroES and DnaK/DnaJ/GrpE foldases (PubMed:29754824). Lacks oxidoreductase activity (PubMed:21498507, PubMed:29754824).<ref>PMID:16563353</ref> <ref>PMID:18657513</ref> <ref>PMID:21498507</ref> <ref>PMID:29754824</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Escherichia coli K-12]] | |||
[[Category: Large Structures]] | |||
[[Category: Kim J]] | |||
[[Category: Roh SH]] | |||
Latest revision as of 07:24, 5 August 2026
AMP-PNP bound E.coli CnoX-GroEL complex, state I
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