9s6f: Difference between revisions
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==Cryo-EM structure of human caspase-9 CARD (WT) filament== | |||
<StructureSection load='9s6f' size='340' side='right'caption='[[9s6f]], [[Resolution|resolution]] 3.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9s6f]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9S6F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9S6F FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9s6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9s6f OCA], [https://pdbe.org/9s6f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9s6f RCSB], [https://www.ebi.ac.uk/pdbsum/9s6f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9s6f ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/CASP9_HUMAN CASP9_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).<ref>PMID:15657060</ref> Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.<ref>PMID:15657060</ref> | ||
[[Category: | == References == | ||
[[Category: | <references/> | ||
[[Category: Rawal | __TOC__ | ||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Alderson TR]] | |||
[[Category: Bohn S]] | |||
[[Category: Desfosses A]] | |||
[[Category: Madl T]] | |||
[[Category: Pavkov-Keller T]] | |||
[[Category: Rawal S]] | |||
Latest revision as of 05:00, 13 August 2026
Cryo-EM structure of human caspase-9 CARD (WT) filament
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