9pxq: Difference between revisions
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==Crystal structure of bovine ALDH3A1 in complex with Canonical Redox Cofactors, NAD+== | |||
<StructureSection load='9pxq' size='340' side='right'caption='[[9pxq]], [[Resolution|resolution]] 1.46Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9pxq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9PXQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9PXQ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.46Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9pxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9pxq OCA], [https://pdbe.org/9pxq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9pxq RCSB], [https://www.ebi.ac.uk/pdbsum/9pxq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9pxq ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: Kim | == Function == | ||
[[Category: Li | [https://www.uniprot.org/uniprot/F1N015_BOVIN F1N015_BOVIN] ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. Oxidizes medium and long chain aldehydes into non-toxic fatty acids. Preferentially oxidizes aromatic aldehyde substrates. Comprises about 50 percent of corneal epithelial soluble proteins. May play a role in preventing corneal damage caused by ultraviolet light.[ARBA:ARBA00045468] | ||
[[Category: Saleh | __TOC__ | ||
</StructureSection> | |||
[[Category: Bos taurus]] | |||
[[Category: Large Structures]] | |||
[[Category: Hsu N]] | |||
[[Category: Kim J]] | |||
[[Category: Li H]] | |||
[[Category: Qiao F]] | |||
[[Category: Saleh S]] | |||
Latest revision as of 16:47, 8 September 2026
Crystal structure of bovine ALDH3A1 in complex with Canonical Redox Cofactors, NAD+
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