9waj: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 9waj is ~~ON HOLD until Paper Publication~~

==Cryo-EM structure of a human sodium pump wildtype in ouabain-bound E2P state==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[9waj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9WAJ OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9WAJ FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.39Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BFD:ASPARTATE+BERYLLIUM+TRIFLUORIDE'>BFD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=OBN:OUABAIN'>OBN</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9waj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9waj OCA], [https://pdbe.org/9waj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9waj RCSB], [https://www.ebi.ac.uk/pdbsum/9waj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9waj ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/AT1B1_HUMAN AT1B1_HUMAN] This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (PubMed:19694409). Plays a role in innate immunity by enhancing virus-triggered induction of interferons (IFNs) and interferon stimulated genes (ISGs). Mechanistically, enhances the ubiquitination of TRAF3 and TRAF6 as well as the phosphorylation of TAK1 and TBK1 (PubMed:34011520).<ref>PMID:19694409</ref> <ref>PMID:34011520</ref> Involved in cell adhesion and establishing epithelial cell polarity.<ref>PMID:19694409</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Abe K]]

[[Category: Gopalasingam CC]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9waj is ON HOLD  until Paper Publication
+==Cryo-EM structure of a human sodium pump wildtype in ouabain-bound E2P state==
+<StructureSection load='9waj' size='340' side='right'caption='[[9waj]], [[Resolution|resolution]] 2.39&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9waj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9WAJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9WAJ FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.39&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BFD:ASPARTATE+BERYLLIUM+TRIFLUORIDE'>BFD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=OBN:OUABAIN'>OBN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9waj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9waj OCA], [https://pdbe.org/9waj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9waj RCSB], [https://www.ebi.ac.uk/pdbsum/9waj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9waj ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/AT1B1_HUMAN AT1B1_HUMAN] This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (PubMed:19694409). Plays a role in innate immunity by enhancing virus-triggered induction of interferons (IFNs) and interferon stimulated genes (ISGs). Mechanistically, enhances the ubiquitination of TRAF3 and TRAF6 as well as the phosphorylation of TAK1 and TBK1 (PubMed:34011520).<ref>PMID:19694409</ref> <ref>PMID:34011520</ref>   Involved in cell adhesion and establishing epithelial cell polarity.<ref>PMID:19694409</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Abe K]]
+[[Category: Gopalasingam CC]]