9y6e: Difference between revisions
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==Crystal structure of PprA from Deinococcus radiodurans in complex with DNA duplex== | |||
<StructureSection load='9y6e' size='340' side='right'caption='[[9y6e]], [[Resolution|resolution]] 5.79Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9y6e]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9Y6E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9Y6E FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 5.79Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9y6e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9y6e OCA], [https://pdbe.org/9y6e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9y6e RCSB], [https://www.ebi.ac.uk/pdbsum/9y6e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9y6e ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: Junop | == Function == | ||
[[Category: Szabla | [https://www.uniprot.org/uniprot/PPRA_DEIRA PPRA_DEIRA] dsDNA-binding protein that contributes to the ionizing radiation resistance of D.radiodurans. Plays a role in DNA repair and genome reconstitution, and is necessary for recovery from severe genomic fragmentation as a result of exposure to severe levels of ionizing radiation. In vitro, binds to double-stranded DNA carrying strand breaks and stimulates the DNA end-joining reaction catalyzed by DNA ligases. Thus, PprA plays a critical role in a non-homologous end-joining (NHEJ) pathway for the repair of radiation-induced DNA double-strands breaks. Cannot bind to dsDNA without strand breaks or single-stranded DNA.<ref>PMID:15454524</ref> <ref>PMID:15458422</ref> | ||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Deinococcus radiodurans]] | |||
[[Category: Large Structures]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Junop MS]] | |||
[[Category: Rok M]] | |||
[[Category: Szabla R]] | |||
Latest revision as of 08:47, 16 September 2026
Crystal structure of PprA from Deinococcus radiodurans in complex with DNA duplex
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