1zt4: Difference between revisions

[[Image:1zt4.gif|left|200px]]<br /><applet load="1zt4" size="350" color="white" frame="true" align="right" spinBox="true"  

The glycolipid alpha-galactosylceramide binds with high affinity to CD1d and stimulates natural killer T cells. Here we report the crystal structure of human CD1d in complex with synthetic alpha-galactosylceramide at a resolution of 3.0 A. The structure shows a tightly fit lipid in the CD1d binding groove, with the sphingosine chain bound in the C' pocket and the longer acyl chain anchored in the A' pocket. We also present the CD1d structure without lipid, which has a more open conformation of the binding groove, suggesting a dual conformation of CD1d in which the 'open' conformation is more able to load lipids. These structures provide clues as to how CD1 molecules load glycolipids as well as data to guide the design of new therapeutic agents.

1ZT4 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=AGH:'>AGH</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZT4 OCA].  

[[Category: Besra, G S.]]

[[Category: Fersht, A R.]]

[[Category: Gadola, S D.]]

[[Category: Jones, E Y.]]

[[Category: SPINE, Structural Proteomics in Europe.]]

[[Category: Schmidt, R R.]]

[[Category: Stronge, V S.]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:18:51 2008''