9sfw: Difference between revisions
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==Structure of Pex8 in complex with peroxisomal receptor Pex5== | |||
<StructureSection load='9sfw' size='340' side='right'caption='[[9sfw]], [[Resolution|resolution]] 4.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9sfw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Komagataella_pastoris Komagataella pastoris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9SFW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9SFW FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.5Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9sfw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9sfw OCA], [https://pdbe.org/9sfw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9sfw RCSB], [https://www.ebi.ac.uk/pdbsum/9sfw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9sfw ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PEX8_PICPA PEX8_PICPA] Essential component of the machinery required for the import of both PTS1 and PTS2 (and perhaps all) peroxisomal matrix proteins (PubMed:7738036). Binding of PEX8 to the N-terminus of PEX5 cargo receptor induces a conformational change of the TPR domains and decrease their binding affinity to cargo, facilitating the release of the PTS1 proteins within the peroxisome (PubMed:23902771).<ref>PMID:23902771</ref> <ref>PMID:7738036</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Komagataella pastoris]] | |||
[[Category: Large Structures]] | |||
[[Category: Chojnowski G]] | |||
[[Category: Ekal L]] | |||
[[Category: Mullapudi E]] | |||
[[Category: Wilmanns M]] | |||
Latest revision as of 16:48, 8 September 2026
Structure of Pex8 in complex with peroxisomal receptor Pex5
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