1wms: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
Line 1: Line 1:
[[Image:1wms.gif|left|200px]]
{{Seed}}
[[Image:1wms.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1wms|  PDB=1wms  |  SCENE=  }}  
{{STRUCTURE_1wms|  PDB=1wms  |  SCENE=  }}  


'''High resolution crystal structure of human Rab9 GTPase: a novel antiviral drug target'''
===High resolution crystal structure of human Rab9 GTPase: a novel antiviral drug target===




==Overview==
<!--  
Rab GTPases and their effectors facilitate vesicular transport by tethering donor vesicles to their respective target membranes. Rab9 mediates late endosome to trans-Golgi transport and has recently been found to be a key cellular component for human immunodeficiency virus-1, Ebola, Marburg, and measles virus replication, suggesting that it may be a novel target in the development of broad spectrum antiviral drugs. As part of our structure-based drug design program, we have determined the crystal structure of a C-terminally truncated human Rab9 (residues 1-177) to 1.25-A resolution. The overall structure shows a characteristic nucleotide binding fold consisting of a six-stranded beta-sheet surrounded by five alpha-helices with a tightly bound GDP molecule in the active site. Structure-based sequence alignment of Rab9 with other Rab proteins reveals that its active site consists of residues highly conserved in the Rab GTPase family, implying a common catalytic mechanism. However, Rab9 contains seven regions that are significantly different in conformation from other Rab proteins. Some of those regions coincide with putative effector-binding sites and switch I and switch II regions identified by structure/sequence alignments. The Rab9 structure at near atomic resolution provides an excellent model for structure-based antiviral drug design.
The line below this paragraph, {{ABSTRACT_PUBMED_15263003}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 15263003 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_15263003}}


==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Zhou, X E.]]
[[Category: Zhou, X E.]]
[[Category: Gtpase]]
[[Category: Gtpase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 13:53:15 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:23:57 2008''

Revision as of 01:24, 29 July 2008

File:1wms.png

Template:STRUCTURE 1wms

High resolution crystal structure of human Rab9 GTPase: a novel antiviral drug target

Template:ABSTRACT PUBMED 15263003

About this Structure

1WMS is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

High resolution crystal structure of human Rab9 GTPase: a novel antiviral drug target., Chen L, DiGiammarino E, Zhou XE, Wang Y, Toh D, Hodge TW, Meehan EJ, J Biol Chem. 2004 Sep 17;279(38):40204-8. Epub 2004 Jul 19. PMID:15263003

Page seeded by OCA on Tue Jul 29 04:23:57 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=1wms&oldid=726912"