9wd9: Difference between revisions
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==GMPCPP-stabilized human alpha1A/beta3 S239C microtubule== | |||
<StructureSection load='9wd9' size='340' side='right'caption='[[9wd9]], [[Resolution|resolution]] 2.26Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9wd9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9WD9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9WD9 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.26Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=G2P:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>G2P</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9wd9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9wd9 OCA], [https://pdbe.org/9wd9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9wd9 RCSB], [https://www.ebi.ac.uk/pdbsum/9wd9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9wd9 ProSAT]</span></td></tr> | ||
[[Category: Luo | </table> | ||
[[Category: | == Disease == | ||
[https://www.uniprot.org/uniprot/TBB3_HUMAN TBB3_HUMAN] Congenital fibrosis of extraocular muscles;Cortical dysgenesis with pontocerebellar hypoplasia due to TUBB3 mutation. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/TBB3_HUMAN TBB3_HUMAN] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. TUBB3 plays a critical role in proper axon guidance and mantainance.<ref>PMID:20074521</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Khoo CJ]] | |||
[[Category: Luo JY]] | |||
[[Category: Ti SC]] | |||
Latest revision as of 16:05, 1 April 2026
GMPCPP-stabilized human alpha1A/beta3 S239C microtubule
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