9sh7: Difference between revisions
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==Crystal structure of DENV3 NS5 methyltransferase domain in complex with TO335 inhibitor== | |||
<StructureSection load='9sh7' size='340' side='right'caption='[[9sh7]], [[Resolution|resolution]] 1.45Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9sh7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_3 Dengue virus 3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9SH7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9SH7 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1JNS:(2~{S})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-[[1-[(3-fluorophenyl)methyl]-1,2,3-triazol-4-yl]methyl]amino]-2-azanyl-butanoic+acid'>A1JNS</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9sh7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9sh7 OCA], [https://pdbe.org/9sh7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9sh7 RCSB], [https://www.ebi.ac.uk/pdbsum/9sh7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9sh7 ProSAT]</span></td></tr> | ||
[[Category: Boura | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/C0LMU0_DENV3 C0LMU0_DENV3] Component of the viral RNA replication complex that functions in virion assembly and antagonizes the host immune response.[ARBA:ARBA00024317] Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.[ARBA:ARBA00003504] RNA-directed RNA polymerase.[PROSITE-ProRule:PRU00539] Regulates the ATPase activity of the NS3 helicase activity. NS4A allows NS3 helicase to conserve energy during unwinding. Plays a role in the inhibition of the host innate immune response. Interacts with host MAVS and thereby prevents the interaction between RIGI and MAVS. In turn, IFN-beta production is impaired. Interacts with host AUP1 which mediates induction of lipophagy in host cells and facilitates production of virus progeny particles.[ARBA:ARBA00045521] Required cofactor for the serine protease function of NS3. May have membrane-destabilizing activity and form viroporins.[ARBA:ARBA00035601] Serine protease NS3: Displays three enzymatic activities: serine protease, NTPase and RNA helicase. NS3 serine protease, in association with NS2B, performs its autocleavage and cleaves the polyprotein at dibasic sites in the cytoplasm: C-prM, NS2A-NS2B, NS2B-NS3, NS3-NS4A, NS4A-2K and NS4B-NS5. NS3 RNA helicase binds RNA and unwinds dsRNA in the 3' to 5' direction.[PROSITE-ProRule:PRU00860] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Dengue virus 3]] | |||
[[Category: Large Structures]] | |||
[[Category: Boura E]] | |||
[[Category: Krafcikova P]] | |||
Latest revision as of 16:49, 8 September 2026
Crystal structure of DENV3 NS5 methyltransferase domain in complex with TO335 inhibitor
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