9ye1: Difference between revisions

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'''Unreleased structure'''


The entry 9ye1 is ON HOLD  until Paper Publication
==Structure-activity-relationship studies of guanidine-based ALDH1B1 inhibitors==
 
<StructureSection load='9ye1' size='340' side='right'caption='[[9ye1]], [[Resolution|resolution]] 2.27&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9ye1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9YE1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9YE1 FirstGlance]. <br>
Description:  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.27&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1CVR:(3M,4R)-1-([1,1-biphenyl]-4-yl)-3-(2-methoxyphenyl)-1,5,6,7-tetrahydroimidazo[1,2-a]pyrimidine'>A1CVR</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ye1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ye1 OCA], [https://pdbe.org/9ye1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ye1 RCSB], [https://www.ebi.ac.uk/pdbsum/9ye1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ye1 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/AL1B1_HUMAN AL1B1_HUMAN] ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation.
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Chen JK]]
[[Category: Fernandez D]]
[[Category: Tarhan K]]
Retrieved from "https://proteopedia.org/9ye1"