1wpq: Difference between revisions

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[[Image:1wpq.gif|left|200px]]
{{Seed}}
[[Image:1wpq.png|left|200px]]


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{{STRUCTURE_1wpq|  PDB=1wpq  |  SCENE=  }}  
{{STRUCTURE_1wpq|  PDB=1wpq  |  SCENE=  }}  


'''Ternary Complex Of Glycerol 3-phosphate Dehydrogenase 1 with NAD and dihydroxyactone'''
===Ternary Complex Of Glycerol 3-phosphate Dehydrogenase 1 with NAD and dihydroxyactone===




==Overview==
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Homo sapiens L-alpha-glycerol-3-phosphate dehydrogenase 1 (GPD1) catalyzes the reversible biological conversion of dihydroxyacetone (DHAP) to glycerol-3-phosphate. The GPD1 protein was expressed in Escherichia coli, and purified as a fusion protein with glutathione S-transferase. Here we report the apoenzyme structure of GPD1 determined by multiwavelength anomalous diffraction phasing, and other complex structures with small molecules (NAD+ and DHAP) by the molecular replacement method. This enzyme structure is organized into two distinct domains, the N-terminal eight-stranded beta-sheet sandwich domain and the C-terminal helical substrate-binding domain. An electrophilic catalytic mechanism by the epsilon-NH3+ group of Lys204 is proposed on the basis of the structural analyses. In addition, the inhibitory effects of zinc and sulfate on GPDHs are assayed and discussed.
The line below this paragraph, {{ABSTRACT_PUBMED_16460752}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16460752 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16460752}}


==About this Structure==
==About this Structure==
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[[Category: Gpd1]]
[[Category: Gpd1]]
[[Category: Nad]]
[[Category: Nad]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 13:59:19 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:49:14 2008''

Revision as of 08:49, 28 July 2008

File:1wpq.png

Template:STRUCTURE 1wpq

Ternary Complex Of Glycerol 3-phosphate Dehydrogenase 1 with NAD and dihydroxyactone

Template:ABSTRACT PUBMED 16460752

About this Structure

1WPQ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structures of human glycerol 3-phosphate dehydrogenase 1 (GPD1)., Ou X, Ji C, Han X, Zhao X, Li X, Mao Y, Wong LL, Bartlam M, Rao Z, J Mol Biol. 2006 Mar 31;357(3):858-69. Epub 2006 Jan 18. PMID:16460752

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