9y2e: Difference between revisions

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'''Unreleased structure'''


The entry 9y2e is ON HOLD  until Paper Publication
==Rubredoxin from Pyrococcus Furiosus at 100K, formyl-Methionine N-terminus==
<StructureSection load='9y2e' size='340' side='right'caption='[[9y2e]], [[Resolution|resolution]] 0.78&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9y2e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9Y2E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9Y2E FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.78&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FME:N-FORMYLMETHIONINE'>FME</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9y2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9y2e OCA], [https://pdbe.org/9y2e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9y2e RCSB], [https://www.ebi.ac.uk/pdbsum/9y2e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9y2e ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RUBR_PYRFU RUBR_PYRFU] Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
How does the structure of a protein change as the temperature is raised from cryogenic conditions at 100 K to 393 K? Understanding the structure and dynamics of proteins under environmental extremes is relevant for human health, biotechnological applications, and our search for life elsewhere in the universe. Here we reveal the high temperature crystal structure of a hyperthermophilic (Pyrococcus furiosus) rubredoxin at 393 K (120 degrees C), together with multiple complementary structures down to 100 K. The results are compared with molecular dynamics calculations. Significant changes in H-bonding are observed. Discussions about high-temperature protein structure and stability need to recognize that low temperature structures may not represent the high temperature case.


Authors:  
Some Like It Hot -Structural Changes in Extremophile Rubredoxin at 120 degrees C.,Doukov T, Leontyev I, Jenney FE Jr, George D, Cramer SP Angew Chem Int Ed Engl. 2026 Jan 28;65(5):e20302. doi: 10.1002/anie.202520302. , Epub 2025 Nov 24. PMID:41287388<ref>PMID:41287388</ref>


Description:  
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
<div class="pdbe-citations 9y2e" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Pyrococcus furiosus]]
[[Category: Cramer SPJ]]
[[Category: Doukov T]]
[[Category: George D]]
[[Category: Jenney FE]]
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