1wq6: Difference between revisions

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[[Image:1wq6.~~gif~~|left|200px]]

[[Image:1wq6.png|left|200px]]

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~~'''~~The tetramer structure of the nervy homolgy two (NHR2) domain of AML1-ETO is critical for AML1-ETO'S activity~~'''~~

===The tetramer structure of the nervy homolgy two (NHR2) domain of AML1-ETO is critical for AML1-ETO'S activity===

~~==Overview==~~

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~~AML1/ETO is the chimeric protein resulting from the t(8;21) in acute myeloid leukemia.~~ The ~~Nervy homology 2 (NHR2) domain in ETO mediates oligomerization and AML1/ETO's interactions with ETO~~, ~~MTGR1~~, ~~and MTG16, and with~~ the ~~corepressor molecules mSin3A and HDAC1 and HDAC3. We solved~~ the ~~NHR2 domain structure and found~~ it ~~to be an alpha-helical tetramer~~. ~~We show that oligomerization contributes to AML1/ETO's inhibition of granulocyte differentiation~~, is ~~essential for its ability to enhance~~ the clonogenic potential of primary mouse bone marrow cells, and affects AML1/ETO's activity on several endogenous genes. Oligomerization is also required for AML1/ETO's interactions with ETO, MTGR1, and MTG16, but not with other corepressor molecules.

The line below this paragraph, {{ABSTRACT_PUBMED_16616331}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 16616331 is the PubMed ID number.

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==About this Structure==

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[[Category: Eto]]

[[Category: Nhr2]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 14~~:00:13 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:00:33 2008''

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-[[Image:1wq6.gif|left|200px]]
+{{Seed}}
+[[Image:1wq6.png|left|200px]]
 <!--
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 {{STRUCTURE_1wq6|  PDB=1wq6  |  SCENE=  }}
-'''The tetramer structure of the nervy homolgy two (NHR2) domain of AML1-ETO is critical for AML1-ETO'S activity'''
+===The tetramer structure of the nervy homolgy two (NHR2) domain of AML1-ETO is critical for AML1-ETO'S activity===
-==Overview==
+<!--
-AML1/ETO is the chimeric protein resulting from the t(8;21) in acute myeloid leukemia. The Nervy homology 2 (NHR2) domain in ETO mediates oligomerization and AML1/ETO's interactions with ETO, MTGR1, and MTG16, and with the corepressor molecules mSin3A and HDAC1 and HDAC3. We solved the NHR2 domain structure and found it to be an alpha-helical tetramer. We show that oligomerization contributes to AML1/ETO's inhibition of granulocyte differentiation, is essential for its ability to enhance the clonogenic potential of primary mouse bone marrow cells, and affects AML1/ETO's activity on several endogenous genes. Oligomerization is also required for AML1/ETO's interactions with ETO, MTGR1, and MTG16, but not with other corepressor molecules.
+The line below this paragraph, {{ABSTRACT_PUBMED_16616331}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16616331 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16616331}}
 ==About this Structure==
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 [[Category: Eto]]
 [[Category: Nhr2]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 14:00:13 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:00:33 2008''