1wrf: Difference between revisions

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[[Image:1wrf.gif|left|200px]]
{{Seed}}
[[Image:1wrf.png|left|200px]]


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{{STRUCTURE_1wrf|  PDB=1wrf  |  SCENE=  }}  
{{STRUCTURE_1wrf|  PDB=1wrf  |  SCENE=  }}  


'''Refined solution structure of Der f 2, The Major Mite Allergen from Dermatophagoides farinae'''
===Refined solution structure of Der f 2, The Major Mite Allergen from Dermatophagoides farinae===




==Overview==
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Group 2 major mite allergens Der f 2 and Der p 2 are classified into the recently identified group of MD-2-related lipid-recognition (ML) proteins, but the ligands and biological functions of these allergens are unknown. We have obtained a high-quality NMR structure for Der f 2, and found that it is more similar to the crystal structure of NPC2, a distant homologue, than to that of Der p 2, in terms of the separation and angle between the two major beta-sheets. This made us propose that ML proteins undergo clamshell-like motions that change the sizes of ligand-binding spaces inside their immunoglobulin-fold beta-sandwich to accommodate lipid molecules. This type of motion in lipopolysaccaride recognition of MD-2 is suggested to be likely as well by structural models. We also report the applicability of NMR differential exchange broadening experiments for complexes of intact monoclonal antibodies and antigens; using this technique, we have detected the conformational epitopes for monoclonal antibodies 15E11 and 13A4 as two separate surface patches.
The line below this paragraph, {{ABSTRACT_PUBMED_15809326}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 15809326 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15809326}}


==About this Structure==
==About this Structure==
1WRF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Dermatophagoides_farinae Dermatophagoides farinae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WRF OCA].  
1WRF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Dermatophagoides_farinae Dermatophagoides farinae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WRF OCA].  


==Reference==
==Reference==
NMR study on the major mite allergen Der f 2: its refined tertiary structure, epitopes for monoclonal antibodies and characteristics shared by ML protein group members., Ichikawa S, Takai T, Inoue T, Yuuki T, Okumura Y, Ogura K, Inagaki F, Hatanaka H, J Biochem. 2005 Mar;137(3):255-63. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15809326 15809326]
NMR study on the major mite allergen Der f 2: its refined tertiary structure, epitopes for monoclonal antibodies and characteristics shared by ML protein group members., Ichikawa S, Takai T, Inoue T, Yuuki T, Okumura Y, Ogura K, Inagaki F, Hatanaka H, J Biochem. 2005 Mar;137(3):255-63. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15809326 15809326]
Solution structure of Der f 2, the major mite allergen for atopic diseases., Ichikawa S, Hatanaka H, Yuuki T, Iwamoto N, Kojima S, Nishiyama C, Ogura K, Okumura Y, Inagaki F, J Biol Chem. 1998 Jan 2;273(1):356-60. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9417088 9417088]
[[Category: Dermatophagoides farinae]]
[[Category: Dermatophagoides farinae]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Allergen]]
[[Category: Allergen]]
[[Category: Immunoglobulin fold]]
[[Category: Immunoglobulin fold]]
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