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[[Image:1wrs.gif|left|200px]]
{{Seed}}
[[Image:1wrs.png|left|200px]]


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{{STRUCTURE_1wrs|  PDB=1wrs  |  SCENE=  }}  
{{STRUCTURE_1wrs|  PDB=1wrs  |  SCENE=  }}  


'''NMR STUDY OF HOLO TRP REPRESSOR'''
===NMR STUDY OF HOLO TRP REPRESSOR===




==Overview==
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The solution structures of the trp-repressor from Escherichia coli in both the liganded (holo-) and unliganded (apo-) form, have been refined by restrained molecular dynamics with simulated annealing using the program XPLOR and additional experimental constraints. The ensemble of refined holorepressor structures have a root-mean-square deviation (r.m.s.d.) of 0.8 A relative to the average structure for the backbone of the dimer core (helices A, B, C, A', B', C') and 2.5 A for the helix-turn-helix DNA-binding domain (helices D and E). The corresponding values for the aporepressor are 0.9 A for the backbone of the ABC-dimer core and 3.2 A for the DE helix-turn-helix. The r.m.s.d. of the average structures from the corresponding crystal structures are 2.3 A for the holorepressor ABC core and 4.2 A for its DE region; 2.3 A for the aporepressor core and 5.5 A for its DE region. The relative disorder of the DNA-binding domain is reflected in a number of experimental parameters including substantially more rapid backbone proton exchange rates, exchange-limited relaxation times and crystallographic B-factors. The stabilizing effect of the L-Trp ligand is evident in these measurements, as it is in the higher precision of the holorepressor structure.
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==About this Structure==
==About this Structure==
1WRS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WRS OCA].  
1WRS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WRS OCA].  


==Reference==
==Reference==
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[[Category: Peptide]]
[[Category: Peptide]]
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:03:41 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat Jul 5 16:21:20 2008''

Revision as of 13:21, 5 July 2008

File:1wrs.png

Template:STRUCTURE 1wrs

NMR STUDY OF HOLO TRP REPRESSOR

Template:ABSTRACT PUBMED 8433368

About this Structure

1WRS is a Single protein structure of sequence from Escherichia coli. Full experimental information is available from OCA.

Reference

Refined solution structures of the Escherichia coli trp holo- and aporepressor., Zhao D, Arrowsmith CH, Jia X, Jardetzky O, J Mol Biol. 1993 Feb 5;229(3):735-46. PMID:8433368

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