9y9q: Difference between revisions
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==Sulfamoyl Fluoride Small Molecules React at Tyrosine and Inhibit Ral GTPases== | |||
<StructureSection load='9y9q' size='340' side='right'caption='[[9y9q]], [[Resolution|resolution]] 1.41Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9y9q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9Y9Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9Y9Q FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.41Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1CUJ:4-[(3-cyclopropyl-2-fluoranyl-phenyl)sulfamoyl]-2-oxidanylidene-pyridine-1-sulfonyl+fluoride'>A1CUJ</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9y9q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9y9q OCA], [https://pdbe.org/9y9q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9y9q RCSB], [https://www.ebi.ac.uk/pdbsum/9y9q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9y9q ProSAT]</span></td></tr> | ||
[[Category: Gonzalez-Gutierrez | </table> | ||
[[Category: Landgraf | == Function == | ||
[https://www.uniprot.org/uniprot/RALA_HUMAN RALA_HUMAN] Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the cytokinetic furrow. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with ADRBK1 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells.<ref>PMID:18756269</ref> <ref>PMID:19306925</ref> <ref>PMID:20005108</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Gonzalez-Gutierrez G]] | |||
[[Category: Landgraf AD]] | |||
[[Category: Meroueh S]] | |||
Latest revision as of 08:12, 9 September 2026
Sulfamoyl Fluoride Small Molecules React at Tyrosine and Inhibit Ral GTPases
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