9yq0: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 9yq0 is ~~ON HOLD~~

==Vacant ribosome with P-site tRNA, substate 2, Structure Ib==

~~Authors~~: ~~Susorov~~, D., ~~Korostelev~~, A.A.

== Structural highlights ==

<table><tr><td colspan='2'>[[9yq0]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9YQ0 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9YQ0 FirstGlance].

~~Description~~: ~~Vacant~~ ribosome with P-site ~~tRNA, substate 2, Structure Ib~~

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.9Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MET:METHIONINE'>MET</scene>, <scene name='pdbligand=SPD:SPERMIDINE'>SPD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

[[Category: ~~Susorov, D~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9yq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9yq0 OCA], [https://pdbe.org/9yq0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9yq0 RCSB], [https://www.ebi.ac.uk/pdbsum/9yq0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9yq0 ProSAT]</td></tr>

[[Category: Korostelev~~, A.A~~]]

</table>

== Function ==

[https://www.uniprot.org/uniprot/RL13A_RABIT RL13A_RABIT] Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex. Involved in methylation of rRNA.[UniProtKB:P40429]

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Oryctolagus cuniculus]]

[[Category: Korostelev AA]]

[[Category: Susorov D]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9yq0 is ON HOLD
+==Vacant ribosome with P-site tRNA, substate 2, Structure Ib==
+<StructureSection load='9yq0' size='340' side='right'caption='[[9yq0]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
-Authors: Susorov, D., Korostelev, A.A.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9yq0]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9YQ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9YQ0 FirstGlance]. <br>
-Description: Vacant ribosome with P-site tRNA, substate 2, Structure Ib
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MET:METHIONINE'>MET</scene>, <scene name='pdbligand=SPD:SPERMIDINE'>SPD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Susorov, D]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9yq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9yq0 OCA], [https://pdbe.org/9yq0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9yq0 RCSB], [https://www.ebi.ac.uk/pdbsum/9yq0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9yq0 ProSAT]</span></td></tr>
-[[Category: Korostelev, A.A]]
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/RL13A_RABIT RL13A_RABIT] Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex. Involved in methylation of rRNA.[UniProtKB:P40429]
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Oryctolagus cuniculus]]
+[[Category: Korostelev AA]]
+[[Category: Susorov D]]