1wt6: Difference between revisions

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[[Image:1wt6.gif|left|200px]]
{{Seed}}
[[Image:1wt6.png|left|200px]]


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{{STRUCTURE_1wt6|  PDB=1wt6  |  SCENE=  }}  
{{STRUCTURE_1wt6|  PDB=1wt6  |  SCENE=  }}  


'''Coiled-Coil domain of DMPK'''
===Coiled-Coil domain of DMPK===


==Overview==
The coiled-coil domain of dystrophia myotonica protein kinase (DMPK) has been cloned, overexpressed, purified and crystallized. Two crystal forms have been obtained that belong to space groups P3 and P2(1)2(1)2(1) and diffract to 2.4 and 1.6 A resolution, respectively. Experimental phases were obtained by MAD from an SeMet derivative. The location of selenium sites used molecular-replacement phases obtained from search models lacking sequence similarity with the coiled-coil under study. Both crystal forms contain three polypeptide chains in the asymmetric unit.


==About this Structure==
==About this Structure==
1WT6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WT6 OCA].  
1WT6 is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WT6 OCA].  


==Reference==
==Reference==
Crystallization and preliminary X-ray analysis of the coiled-coil domain of dystrophia myotonica kinase., Garcia P, Marino M, Mayans O, Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 2):2336-9. Epub, 2004 Nov 26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15583383 15583383]
<ref group="xtra">PMID:15583383</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Garcia, P.]]
[[Category: Garcia, P.]]
[[Category: Marino, M.]]
[[Category: Marino, M.]]
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[[Category: Kinase activation]]
[[Category: Kinase activation]]
[[Category: Molecular replacement]]
[[Category: Molecular replacement]]
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