9q3f: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==Structure of neurodevelopmental mutant AGO1 F180del in complex with guide RNA== | |||
<StructureSection load='9q3f' size='340' side='right'caption='[[9q3f]], [[Resolution|resolution]] 3.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9q3f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Trichoplusia_ni Trichoplusia ni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9Q3F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9Q3F FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9q3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9q3f OCA], [https://pdbe.org/9q3f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9q3f RCSB], [https://www.ebi.ac.uk/pdbsum/9q3f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9q3f ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/AGO1_HUMAN AGO1_HUMAN] Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs).<ref>PMID:16289642</ref> <ref>PMID:16936728</ref> <ref>PMID:18771919</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Trichoplusia ni]] | |||
[[Category: Adhav V]] | |||
[[Category: Fu T]] | |||
[[Category: Nakanishi K]] | |||
[[Category: Savidge A]] | |||
[[Category: Shen Z]] | |||
Latest revision as of 09:40, 6 November 2025
Structure of neurodevelopmental mutant AGO1 F180del in complex with guide RNA
| ||||||||||||
