9t2i: Difference between revisions

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'''Unreleased structure'''


The entry 9t2i is ON HOLD
==SP100 nuclear antigen with crystallization epitope mutations N816D:T820R==
 
<StructureSection load='9t2i' size='340' side='right'caption='[[9t2i]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
Authors: Fairhead, M., Strain-Damerell, C., Ye, M., Mackinnon, S.R., Pinkas, D., MacLean, E.M., Koekemoer, L., Damerell, D., Krojer, T., Arrowsmith, C.H., Edwards, A., Bountra, C., Yue, W., Burgess-Brown, N., Marsden, B., von Delft, F.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9t2i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9T2I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9T2I FirstGlance]. <br>
Description: SP100 nuclear antigen with crystallization epitope mutations N816D:T820R
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.35&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
[[Category: Bountra, C]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9t2i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9t2i OCA], [https://pdbe.org/9t2i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9t2i RCSB], [https://www.ebi.ac.uk/pdbsum/9t2i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9t2i ProSAT]</span></td></tr>
[[Category: Strain-Damerell, C]]
</table>
[[Category: Pinkas, D]]
== Function ==
[[Category: Edwards, A]]
[https://www.uniprot.org/uniprot/SP100_HUMAN SP100_HUMAN] Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation.<ref>PMID:11909962</ref> <ref>PMID:14647468</ref> <ref>PMID:15247905</ref> <ref>PMID:15592518</ref> <ref>PMID:15767676</ref> <ref>PMID:16177824</ref> <ref>PMID:17245429</ref> <ref>PMID:21274506</ref> <ref>PMID:21880768</ref>
[[Category: Von Delft, F]]
== References ==
[[Category: Koekemoer, L]]
<references/>
[[Category: Ye, M]]
__TOC__
[[Category: Mackinnon, S.R]]
</StructureSection>
[[Category: Fairhead, M]]
[[Category: Homo sapiens]]
[[Category: Damerell, D]]
[[Category: Large Structures]]
[[Category: Marsden, B]]
[[Category: Arrowsmith CH]]
[[Category: Yue, W]]
[[Category: Bountra C]]
[[Category: Burgess-Brown, N]]
[[Category: Burgess-Brown N]]
[[Category: Maclean, E.M]]
[[Category: Damerell D]]
[[Category: Krojer, T]]
[[Category: Edwards A]]
[[Category: Arrowsmith, C.H]]
[[Category: Fairhead M]]
[[Category: Koekemoer L]]
[[Category: Krojer T]]
[[Category: MacLean EM]]
[[Category: Mackinnon SR]]
[[Category: Marsden B]]
[[Category: Pinkas D]]
[[Category: Strain-Damerell C]]
[[Category: Ye M]]
[[Category: Yue W]]
[[Category: Von Delft F]]
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