9wlr: Difference between revisions

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'''Unreleased structure'''


The entry 9wlr is ON HOLD  until Paper Publication
==Cryo-EM structure of human papillomavirus type 45==
 
<StructureSection load='9wlr' size='340' side='right'caption='[[9wlr]], [[Resolution|resolution]] 3.95&Aring;' scene=''>
Authors: Jiang, Y., Sun, H., Zheng, Q., Li, S.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9wlr]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_papillomavirus_45 Human papillomavirus 45]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9WLR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9WLR FirstGlance]. <br>
Description: Cryo-EM structure of human papillomavirus type 45
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.95&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9wlr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9wlr OCA], [https://pdbe.org/9wlr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9wlr RCSB], [https://www.ebi.ac.uk/pdbsum/9wlr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9wlr ProSAT]</span></td></tr>
[[Category: Jiang, Y]]
</table>
[[Category: Sun, H]]
== Function ==
[[Category: Zheng, Q]]
[https://www.uniprot.org/uniprot/VL1_HPV45 VL1_HPV45] Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.[HAMAP-Rule:MF_04002]
[[Category: Li, S]]
__TOC__
</StructureSection>
[[Category: Human papillomavirus 45]]
[[Category: Large Structures]]
[[Category: Jiang Y]]
[[Category: Li S]]
[[Category: Sun H]]
[[Category: Zheng Q]]
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