1ww1: Difference between revisions

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[[Image:1ww1.~~gif~~|left|200px]]

[[Image:1ww1.png|left|200px]]

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~~'''~~Crystal structure of tRNase Z from Thermotoga maritima~~'''~~

===Crystal structure of tRNase Z from Thermotoga maritima===

~~==Overview==~~

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The ~~maturation of the tRNA 3' end is catalyzed by a tRNA 3' processing endoribonuclease named tRNase Z (RNase Z or 3'-tRNase) in eukaryotes~~, ~~Archaea~~, ~~and some bacteria. The tRNase Z generally cuts~~ the ~~3' extra sequence from~~ the ~~precursor tRNA after the discriminator nucleotide~~. ~~In contrast, Thermotoga maritima tRNase Z cleaves the precursor tRNA precisely after the CCA sequence~~. ~~In this study~~, ~~we determined~~ the ~~crystal structure of T~~. ~~maritima tRNase Z at 2.6~~-~~A resolution. The tRNase Z has a four~~-layer alphabeta/betaalpha sandwich fold, which is classified as a metallo-beta-lactamase fold, and forms a dimer. The active site is located at one edge of the beta-sandwich and is composed of conserved motifs. Based on the structure, we constructed a docking model with the tRNAs that suggests how tRNase Z may recognize the substrate tRNAs.

The line below this paragraph, {{ABSTRACT_PUBMED_15701599}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 15701599 is the PubMed ID number.

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==About this Structure==

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[[Category: Rsgi]]

[[Category: Structural genomic]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3~~ 14:12:42 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:28:37 2008''

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-[[Image:1ww1.gif|left|200px]]
+{{Seed}}
+[[Image:1ww1.png|left|200px]]
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 {{STRUCTURE_1ww1|  PDB=1ww1  |  SCENE=  }}
-'''Crystal structure of tRNase Z from Thermotoga maritima'''
+===Crystal structure of tRNase Z from Thermotoga maritima===
-==Overview==
+<!--
-The maturation of the tRNA 3' end is catalyzed by a tRNA 3' processing endoribonuclease named tRNase Z (RNase Z or 3'-tRNase) in eukaryotes, Archaea, and some bacteria. The tRNase Z generally cuts the 3' extra sequence from the precursor tRNA after the discriminator nucleotide. In contrast, Thermotoga maritima tRNase Z cleaves the precursor tRNA precisely after the CCA sequence. In this study, we determined the crystal structure of T. maritima tRNase Z at 2.6-A resolution. The tRNase Z has a four-layer alphabeta/betaalpha sandwich fold, which is classified as a metallo-beta-lactamase fold, and forms a dimer. The active site is located at one edge of the beta-sandwich and is composed of conserved motifs. Based on the structure, we constructed a docking model with the tRNAs that suggests how tRNase Z may recognize the substrate tRNAs.
+The line below this paragraph, {{ABSTRACT_PUBMED_15701599}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15701599 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_15701599}}
 ==About this Structure==
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 [[Category: Rsgi]]
 [[Category: Structural genomic]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 14:12:42 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:28:37 2008''