9yiy: Difference between revisions
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==Crystal structure of mouse coatomer beta2-WD40 domain in complex with MHV spike tail hepta-peptide== | |||
<StructureSection load='9yiy' size='340' side='right'caption='[[9yiy]], [[Resolution|resolution]] 1.36Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9yiy]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Murine_hepatitis_virus_strain_A59 Murine hepatitis virus strain A59] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9YIY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9YIY FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.36Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9yiy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9yiy OCA], [https://pdbe.org/9yiy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9yiy RCSB], [https://www.ebi.ac.uk/pdbsum/9yiy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9yiy ProSAT]</span></td></tr> | ||
[[Category: Dey | </table> | ||
[[Category: Hasan | == Function == | ||
[https://www.uniprot.org/uniprot/COPB2_MOUSE COPB2_MOUSE] The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Murine hepatitis virus strain A59]] | |||
[[Category: Mus musculus]] | |||
[[Category: Dey D]] | |||
[[Category: Hasan SS]] | |||
[[Category: Shakya AK]] | |||
Latest revision as of 07:15, 7 October 2026
Crystal structure of mouse coatomer beta2-WD40 domain in complex with MHV spike tail hepta-peptide
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