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==Structure Tour== | ==Structure Tour== | ||
<StructureSection load='9kkk' size='340' side='right'caption='Cryo-EM structure of human SLC22A6 (OAT1) in the apo-state, [[Resolution|resolution]] 3.85Å' scene=''> | <StructureSection load='9kkk' size='340' side='right'caption='Cryo-EM structure of human SLC22A6 (OAT1) in the apo-state, [[Resolution|resolution]] 3.85Å' scene=''> | ||
=== | ===Introduction=== | ||
Members of the organic anion transporter (OAT) family, including | Members of the organic anion transporter (OAT) family, including | ||
OAT1, are expressed on the epithelial membrane of the kidney, | OAT1, are expressed on the epithelial membrane of the kidney, | ||
liver, brain, intestine, and placenta. OAT1 regulates the transport | liver, brain, intestine, and placenta.<ref>Molecular cloning and characterization of a novel liver-specific transport protein https://doi.org/10.1242/jcs.107.4.1065</ref><ref>Molecular Cloning and Characterization of NKT, a Gene Product Related to the Organic Cation Transporter Family That Is Almost Exclusively Expressed in the Kidney https://doi.org/10.1074/jbc.272.10.6471</ref> OAT1 regulates the transport | ||
of organic anion drugs from the blood into kidney epithelial | of organic anion drugs from the blood into kidney epithelial | ||
cells by utilizing the α-ketoglutarate (α-KG) gradient across the | cells by utilizing the α-ketoglutarate (α-KG) gradient across the | ||
