HOAT1: Difference between revisions
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===Cryo-EM structure of hOAT1=== | ===Cryo-EM structure of hOAT1=== | ||
[[Image:Hoat1domain.png]] | [[Image:Hoat1domain.png |frame| right| Fig1.]] | ||
The apo state structure of human Organic Anion Transporter 1 (hOAT1), determined by cryo-EM, reveals the transporter in an inward-facing conformation. This means the central substrate-binding cavity is open toward the intracellular side of the membrane, ready to release a substrate or accept one from the cytoplasm. | The apo state structure of human Organic Anion Transporter 1 (hOAT1), determined by cryo-EM, reveals the transporter in an inward-facing conformation. This means the central substrate-binding cavity is open toward the intracellular side of the membrane, ready to release a substrate or accept one from the cytoplasm. | ||
