HOAT1: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 51: | Line 51: | ||
===Cryo-EM structure of hOAT1=== | ===Cryo-EM structure of hOAT1=== | ||
[[Image:Hoat1domain.png |frame| right| | [[Image:Hoat1domain.png |200 px|frame| right| Fig 1. (A) Schematic diagram of human OAT1 topology | ||
and the overall transport process.]] | |||
The apo state structure of human Organic Anion Transporter 1 (hOAT1), determined by cryo-EM, reveals the transporter in an inward-facing conformation. This means the central substrate-binding cavity is open toward the intracellular side of the membrane, ready to release a substrate or accept one from the cytoplasm. | The apo state structure of human Organic Anion Transporter 1 (hOAT1), determined by cryo-EM, reveals the transporter in an inward-facing conformation. This means the central substrate-binding cavity is open toward the intracellular side of the membrane, ready to release a substrate or accept one from the cytoplasm. | ||
