Nithin 6wxd: Difference between revisions
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Functionally, it stabilizes the substrate as it enters the active site and helps maintain the enzyme’s catalytic geometry. | Functionally, it stabilizes the substrate as it enters the active site and helps maintain the enzyme’s catalytic geometry. | ||
Because of its β-barrel framework, Domain I gives both stability and specificity to the protease. | Because of its β-barrel framework, Domain I gives both stability and specificity to the protease. | ||
Domain II (residues 102–184) continues the β-barrel architecture and contains Cys145, forming the second half of the His41–Cys145 catalytic dyad. Together, | <scene name='10/1096916/Domain_ii/1'>Domain II (residues 102–184)</scene> continues the β-barrel architecture and contains Cys145, forming the second half of the His41–Cys145 catalytic dyad. Together, | ||
Domains I and II generate the deep substrate-binding | Domains I and II generate the deep substrate-binding | ||
groove that includes the S1, S2, and S4 pockets essential for recognizing viral polyprotein | groove that includes the S1, S2, and S4 pockets essential for recognizing viral polyprotein | ||
