Nithin 6wxd: Difference between revisions
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The catalytic activity of the SARS-CoV-2 Main Protease (Mpro) is driven by a conserved **His41–Cys145 catalytic dyad**. This dyad carries out peptide bond hydrolysis and is essential for all cleavage reactions during viral polyprotein processing. | The catalytic activity of the SARS-CoV-2 Main Protease (Mpro) is driven by a conserved **His41–Cys145 catalytic dyad**. This dyad carries out peptide bond hydrolysis and is essential for all cleavage reactions during viral polyprotein processing. | ||
* '''His41''' functions as a general base. It extracts a proton from Cys145, converting it into a highly reactive thiolate. | * '''<scene name='10/1096916/His41/1'>His41</scene>''' functions as a general base. It extracts a proton from Cys145, converting it into a highly reactive thiolate. | ||
* '''Cys145''' acts as the nucleophile. Once activated, it attacks the carbonyl carbon of the substrate’s scissile peptide bond. | * '''Cys145''' acts as the nucleophile. Once activated, it attacks the carbonyl carbon of the substrate’s scissile peptide bond. | ||
