2a5e: Difference between revisions

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[[Image:2a5e.gif|left|200px]]<br />

[[Image:2a5e.gif|left|200px]]<br /><applet load="2a5e" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="2a5e" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="2a5e" />

'''SOLUTION NMR STRUCTURE OF TUMOR SUPPRESSOR P16INK4A, RESTRAINED MINIMIZED MEAN STRUCTURE'''<br />

==Overview==

The solution structure of the tumor suppressor p16INK4A has been, determined by NMR, and important recognition regions of both cdk4 and, p16INK4A have been identified. The tertiary structure of p16INK4A contains, four helix-turn-helix motifs linked by three loops. Twelve tumorigenic, mutants of p16INK4A have been constructed and analyzed for their structure, and activity, and new mutants have been designed rationally. A fragment of, 58 residues at the N terminus of cdk4 important for p16INK4A binding has, been identified. The importance of this region was further verified by, mutational analysis of cdk4. These results and docking experiments have, been used to assess possible modes of binding between p16INK4A and cdk4.

The solution structure of the tumor suppressor p16INK4A has been determined by NMR, and important recognition regions of both cdk4 and p16INK4A have been identified. The tertiary structure of p16INK4A contains four helix-turn-helix motifs linked by three loops. Twelve tumorigenic mutants of p16INK4A have been constructed and analyzed for their structure and activity, and new mutants have been designed rationally. A fragment of 58 residues at the N terminus of cdk4 important for p16INK4A binding has been identified. The importance of this region was further verified by mutational analysis of cdk4. These results and docking experiments have been used to assess possible modes of binding between p16INK4A and cdk4.

==Disease==

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==About this Structure==

2A5E is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=2A5E OCA].

2A5E is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A5E OCA].

==Reference==

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[[Category: Homo sapiens]]

[[Category: Single protein]]

[[Category: Byeon, I.J.L.]]

[[Category: Byeon, I J.L.]]

[[Category: Ericson, K.]]

[[Category: Kim, H.J.]]

[[Category: Kim, H J.]]

[[Category: Li, J.]]

[[Category: Maille, P.O.]]

[[Category: Maille, P O.]]

[[Category: Selby, T.L.]]

[[Category: Selby, T L.]]

[[Category: Tevelev, A.]]

[[Category: Tsai, M.D.]]

[[Category: Tsai, M D.]]

[[Category: anti-oncogene]]

[[Category: tumor-suppressor-p16ink4a]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov 12 20~~:46:~~29 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:23:45 2008''

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@@ Line 1: / Line 1: @@
-[[Image:2a5e.gif|left|200px]]<br />
+[[Image:2a5e.gif|left|200px]]<br /><applet load="2a5e" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="2a5e" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="2a5e" />
 '''SOLUTION NMR STRUCTURE OF TUMOR SUPPRESSOR P16INK4A, RESTRAINED MINIMIZED MEAN STRUCTURE'''<br />
 ==Overview==
-The solution structure of the tumor suppressor p16INK4A has been, determined by NMR, and important recognition regions of both cdk4 and, p16INK4A have been identified. The tertiary structure of p16INK4A contains, four helix-turn-helix motifs linked by three loops. Twelve tumorigenic, mutants of p16INK4A have been constructed and analyzed for their structure, and activity, and new mutants have been designed rationally. A fragment of, 58 residues at the N terminus of cdk4 important for p16INK4A binding has, been identified. The importance of this region was further verified by, mutational analysis of cdk4. These results and docking experiments have, been used to assess possible modes of binding between p16INK4A and cdk4.
+The solution structure of the tumor suppressor p16INK4A has been determined by NMR, and important recognition regions of both cdk4 and p16INK4A have been identified. The tertiary structure of p16INK4A contains four helix-turn-helix motifs linked by three loops. Twelve tumorigenic mutants of p16INK4A have been constructed and analyzed for their structure and activity, and new mutants have been designed rationally. A fragment of 58 residues at the N terminus of cdk4 important for p16INK4A binding has been identified. The importance of this region was further verified by mutational analysis of cdk4. These results and docking experiments have been used to assess possible modes of binding between p16INK4A and cdk4.
 ==Disease==
@@ Line 11: / Line 10: @@
 ==About this Structure==
-A5E is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2A5E OCA].
+A5E is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A5E OCA].
 ==Reference==
@@ Line 17: / Line 16: @@
 [[Category: Homo sapiens]]
 [[Category: Single protein]]
-[[Category: Byeon, I.J.L.]]
+[[Category: Byeon, I J.L.]]
 [[Category: Ericson, K.]]
-[[Category: Kim, H.J.]]
+[[Category: Kim, H J.]]
 [[Category: Li, J.]]
-[[Category: Maille, P.O.]]
+[[Category: Maille, P O.]]
-[[Category: Selby, T.L.]]
+[[Category: Selby, T L.]]
 [[Category: Tevelev, A.]]
-[[Category: Tsai, M.D.]]
+[[Category: Tsai, M D.]]
 [[Category: anti-oncogene]]
 [[Category: tumor-suppressor-p16ink4a]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 20:46:29 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:23:45 2008''