1x18: Difference between revisions

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[[Image:1x18.gif|left|200px]]
{{Seed}}
[[Image:1x18.png|left|200px]]


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{{STRUCTURE_1x18|  PDB=1x18  |  SCENE=  }}  
{{STRUCTURE_1x18|  PDB=1x18  |  SCENE=  }}  


'''Contact sites of ERA GTPase on the THERMUS THERMOPHILUS 30S SUBUNIT'''
===Contact sites of ERA GTPase on the THERMUS THERMOPHILUS 30S SUBUNIT===




==Overview==
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Era (E. coliRas-like protein) is a highly conserved and essential GTPase in bacteria. It binds to the 16S ribosomal RNA (rRNA) of the small (30S) ribosomal subunit, and its depletion leads to accumulation of an unprocessed precursor of the 16S rRNA. We have obtained a three-dimensional cryo-electron microscopic map of the Thermus thermophilus 30S-Era complex. Era binds in the cleft between the head and platform of the 30S subunit and locks the subunit in a conformation that is not favorable for association with the large (50S) ribosomal subunit. The RNA binding KH motif present within the C-terminal domain of Era interacts with the conserved nucleotides in the 3' region of the 16S rRNA. Furthermore, Era makes contact with several assembly elements of the 30S subunit. These observations suggest a direct involvement of Era in the assembly and maturation of the 30S subunit.
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{{ABSTRACT_PUBMED_15866174}}


==About this Structure==
==About this Structure==
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==Reference==
==Reference==
Interaction of Era with the 30S ribosomal subunit implications for 30S subunit assembly., Sharma MR, Barat C, Wilson DN, Booth TM, Kawazoe M, Hori-Takemoto C, Shirouzu M, Yokoyama S, Fucini P, Agrawal RK, Mol Cell. 2005 Apr 29;18(3):319-29. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15866174 15866174]
Interaction of Era with the 30S ribosomal subunit implications for 30S subunit assembly., Sharma MR, Barat C, Wilson DN, Booth TM, Kawazoe M, Hori-Takemoto C, Shirouzu M, Yokoyama S, Fucini P, Agrawal RK, Mol Cell. 2005 Apr 29;18(3):319-29. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15866174 15866174]
Structure of the 30S ribosomal subunit., Wimberly BT, Brodersen DE, Clemons WM Jr, Morgan-Warren RJ, Carter AP, Vonrhein C, Hartsch T, Ramakrishnan V, Nature. 2000 Sep 21;407(6802):327-39. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11014182 11014182]
Crystal structure of ERA: a GTPase-dependent cell cycle regulator containing an RNA binding motif., Chen X, Court DL, Ji X, Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8396-401. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10411886 10411886]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: Sharma, M R.]]
[[Category: Sharma, M R.]]
[[Category: Contact sites of era protein on the 30s ribosomal subunit]]
[[Category: Contact sites of era protein on the 30s ribosomal subunit]]
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