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| [[Image:1x22.gif|left|200px]] | | {{Seed}} |
| | [[Image:1x22.png|left|200px]] |
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| {{STRUCTURE_1x22| PDB=1x22 | SCENE= }} | | {{STRUCTURE_1x22| PDB=1x22 | SCENE= }} |
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| '''Solution structure of a novel moricin analogue, an antibacterial peptide from a lepidopteran insect, Spodoptera litura'''
| | ===Solution structure of a novel moricin analogue, an antibacterial peptide from a lepidopteran insect, Spodoptera litura=== |
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| ==Overview==
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| An antibacterial peptide was isolated from a lepidopteran insect, Spodoptera litura. The molecular mass of this peptide was determined to be 4489.55 by matrix assisted laser desorption/ionization-time of flight mass (MALDI-TOF MS) spectrometry. The peptide consists of 42 amino acids and the sequence has 69-98% identity to those of moricin-related peptides, antibacterial peptides from lepidopetran insects. Thus, the peptide was designated S. litura (Sl) moricin. Sl moricin showed a broad antibacterial spectrum against Gram-positive and negative bacteria. Sl moricin gene was inducible by bacterial injection and expressed tissue-specifically in the fat body and hemocytes. Furthermore, the solution structure of Sl moricin was determined by two-dimensional (2D) 1H-nuclear magnetic resonance (NMR) spectroscopy and hybrid distance geometry-simulated annealing calculation. The tertiary structure revealed a long alpha-helix containing eight turns along nearly the full length of the peptide like that of moricin, confirming that Sl moricin is a new moricin-like antibacterial peptide. These results suggest that moricin is present not only in B. mori but also in other lepidopteran insects forming a gene family.
| | The line below this paragraph, {{ABSTRACT_PUBMED_16115804}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 16115804 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_16115804}} |
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| ==About this Structure== | | ==About this Structure== |
| 1X22 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X22 OCA]. | | 1X22 is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X22 OCA]. |
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| ==Reference== | | ==Reference== |
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| [[Category: Purification]] | | [[Category: Purification]] |
| [[Category: Solution structure]] | | [[Category: Solution structure]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:25:48 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:31:33 2008'' |
