9xi8: Difference between revisions

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'''Unreleased structure'''


The entry 9xi8 is ON HOLD  until Paper Publication
==Sarbecovirus GX2013 Spike S1 in complex with C092 Fab==
 
<StructureSection load='9xi8' size='340' side='right'caption='[[9xi8]], [[Resolution|resolution]] 3.45&Aring;' scene=''>
Authors: Niu, C., Liu, B., Gao, X., Li, Z., He, J., Xiong, X.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9xi8]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/BtRs-BetaCoV/GX2013 BtRs-BetaCoV/GX2013] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9XI8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9XI8 FirstGlance]. <br>
Description: Sarbecovirus GX2013 Spike S1 in complex with C092 Fab
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.45&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9xi8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9xi8 OCA], [https://pdbe.org/9xi8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9xi8 RCSB], [https://www.ebi.ac.uk/pdbsum/9xi8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9xi8 ProSAT]</span></td></tr>
[[Category: He, J]]
</table>
[[Category: Xiong, X]]
== Function ==
[[Category: Li, Z]]
[https://www.uniprot.org/uniprot/A0A0U1WHJ8_SARS A0A0U1WHJ8_SARS] Spike protein S1: attaches the virion to the cell membrane by interacting with host receptor, initiating the infection.[HAMAP-Rule:MF_04099]  Spike protein S2': Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099]  Spike protein S2: mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099]
[[Category: Liu, B]]
__TOC__
[[Category: Gao, X]]
</StructureSection>
[[Category: Niu, C]]
[[Category: BtRs-BetaCoV/GX2013]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Gao X]]
[[Category: He J]]
[[Category: Li Z]]
[[Category: Liu B]]
[[Category: Niu C]]
[[Category: Xiong X]]
Retrieved from "https://proteopedia.org/9xi8"